1. Agenda 9/27 Antibiotic Resistance Lecture
Antibiotic Resistance Case Study
Introduce antibacterial project
Homework:
1. Chp 23 reading and notes (due 10/2)
2. Genetic Drift Video and Notes
Turn in: Video notes and dog’s decoded answers

2. Questions
Why is using antibacterial products producing more resistant bacteria?
Why is this a growing problem?
How does using antibiotics in farming results in problems for humans?
Can antibiotic resistance spread?
Why is it so important to take the full dose of an antibiotic?
How does this relate to evolution?
What’s the deal with MRSA?
What can we do?

3. How does this relate to evolution?
The bacteria developing a random mutation for antibiotic resistance is the starting point for natural selection
Then, in the presence of antibiotics, there is an advantage for the resistant bacteria
They have an increased fitness when compared to antibiotic sensitive bacteria
Over time, those resistant bacteria survive longer and reproduce more meaning a larger proportion of the population will possess antibiotic resistant genes

4. Antibacterial Products
These are found in soap, wipes, hand sanitizer, household cleaners etc.
As you use these products, they kill bacteria that are sensitive to the antibiotics
The bacteria that are resistant survive, and reproduce, passing their resistant genes on

5. Resistant Genes Can Spread
Bacteria can share genetic material through a process called conjugation
This means, if one cell becomes resistant it can spread to other cells in the population

6. Farming an antibiotics
When antibiotics are regularly fed to animals, it provides a selective advantage to resistant bacteria in those animals
When the meat is not cooked or handled properly, those resistant bacteria can spread to humans

7. Taking the full dose of antibiotics
It is important to take the entire dose of antibiotics when you are sick to ensure your do not get a 2nd infection that is harder to treat with antibiotics

8. Initial Treatment Re-treatment
Now you aren’t ever going to get below the immune threshold
Antibiotic-sensitive
Antibiotic-resistant

9. MRSA (methicillin resistant staphylococcus aureus)

10. What can we do?

11. Evolution Soap/Antibacterial Project
3 Parts
1. A proposal to persuade administrators and teacher to not use antibacterial products in the school (soap, hand sanitizers, cleaners)
2. A meeting with an administrator to give a brief overview of your proposal
3. A reflection of that meeting
Additional Requirements
In your proposal you must use 2 peer reviewed sources and at least 5 other sources
All writing must be summarized in your own words
In-text citations and a bibliography required (MLA format)
You must prepare for your meeting, be professional, and plan to keep it to 10 minutes

12. Due Dates Group progress form: due 10/1 in class
Your sources: due 10/1 by 11:59 PM
Written proposal: due 10/3 by 11:59 PM
Meeting reflection: due 10/11 by 11:59 PM
Questions?