1. Signal Transduction Pathways and Cell Differentiation
Stem Cell
Specialized cell type
(neuron, skin cell, red blood cell, etc.)

2. Blood Cell Formation

3. Red Blood Cell Development

4. EPO
Synthesis of proteins that
stimulate Red Blood Cell development

5. Negative Regulation of JAK/STAT Pathway

6. Tubulin Dimer
GTP
GTP
Taxol

8. Centrosome Structure

11. Pg. 583

12. Microtubule “Poisons”
Colchicine
Taxol
(Autumn crocus)
(Pacific Yew)

13. Microtubule “Motor” Proteins

15. Microtubule “Motor” Proteins

16. Microtubules Help to Organize the Cytoplasm

18. Actin Filaments

19. Actin Monomer

21. Arp2/3 (Actin Related Proteins)

23. Actin-GFP
Actin
Cable
Cortical
Actin
Patch

24. Actin Cables and Actin Patches

25. Thrombin
Resting
Platlet
Activated
Platlet

26. Gelsolin Protein
New minus end

29. Myosin-II

30. Muscle Cell

31. Sarcomere

32. Contraction of a Sarcomere

33. Resting Muscle

34. Ca2+
Binds
Troponin C

36. Muscle Cell

38. Pg. 574

39. Pg. 576

40. Plectin Protein
Plectin
Microtubule
Intermediate
Filament
Pg. 578

41. Pg. 577

42. Mitotic Cell Cycle
DNA
Replication

43. G1 S G2
M-Phase G1

45. Binding site for
Origin Recognition Complex (ORC)
(ORC)

46. Semi-Conservative DNA Replication
(G1 Phase)
(G2 Phase)

50. Completing Synthesis of the Lagging Strand*
(5’ to 3” exonuclease) *

51. DNA Polymerase “proof reading”

52. Thymine Tautomers Pairs with Adenine Pairs with Guanine (common form)
(rare form)
Pairs with Adenine
Pairs with Guanine

53. Telomere Structure
T-Loop
Telomere (red)

54. End Replication Problem
First round of
DNA replication *
Final RNA primers
removed * *
Second round of
DNA replication *

55. Telomere Synthesis

56. Telomere Synthesis