1. SUMOylation Places LRH-1 in PROXimity to Lipid Metabolism
Christina Priest, Peter Tontonoz 
Cell Metabolism 
Volume 20, Issue 4, Pages (October 2014)
DOI: /j.cmet
Copyright © 2014 Elsevier Inc. Terms and Conditions

2. Figure 1
SUMOylation of LRH-1 Promotes Its Interaction with PROX1 and Inhibits Gene Expression Linked to Reverse Cholesterol Transport
LRH-1 promotes transcription of genes involved in hepatic reverse cholesterol transport including Scarb1, Abgc5, and Abcg8. Expression of these genes contributes to increased hepatic cholesterol uptake and excretion. SUMOylation of LRH-1 promotes its interaction with the transcriptional repressor PROX1 and thereby inhibits target gene expression, inhibits reverse cholesterol transport (RCT), and increases susceptibility to atherosclerosis.
Cell Metabolism  , DOI: ( /j.cmet )
Copyright © 2014 Elsevier Inc. Terms and Conditions