1. Clinical Genomics: Interoperability & Value-Based Medicine
Peter Paul Yu, MD
Hartford HealthCare Cancer Institute
MSK Cancer Alliance

2. Cancer Data Ecosystem Genomics Institute Patients Internet of Things
Genomic Data
Sources
Genomics Institute
Research Networks and Knowledge Base
Clinical Networks and Knowledge Base
Patients
Internet of Things
Providers
Payers
Labs
Imaging
Patient Data
Sources

3. Interoperability

4. Value Based Medicine Outcomes Shared Decision Making
Clinical Decision Support Systems
Patient Data
Clinical Practice Guidelines KB
Systems Biology KB
Real World/Health Systems KB

5. Clinical Care Access to KBs-Clinical Annotation Visualization Tools
PM trial matching
Specialty pharmacy
Coverage
Patient engagement

6. Recommendations Interoperability Value Based Medicine
Across Data Ecosystem
Federal: FDA, SEER & CDC
AJCC Molecular Staging
CAP Biomarker & eCC
GA4GH API’s & HL7 FHIR
ASCO CancerLinQ
Molecular Tumor Boards
Clinical Utility of testing-Payers
Guidelines
Patient Centered Outcomes
Clinical Decision Support
Department of HHS
Medicare APM/OCM
MACRA-Meaningful Use
Part B Drug Payment Model
Reference-based
Indication-based
Outcomes-based