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Christina A. de Fontnouvelle, BS, Jason H

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1 Interleukin-8 and Tumor Necrosis Factor Predict Acute Kidney Injury After Pediatric Cardiac Surgery 
Christina A. de Fontnouvelle, BS, Jason H. Greenberg, MD, MHS, Heather R. Thiessen-Philbrook, MMath, Michael Zappitelli, MD, MS, Jeremy Roth, BA, Kathleen F. Kerr, PhD, Prasad Devarajan, MD, Michael Shlipak, MD, Steven Coca, DO, MS, Chirag R. Parikh, MD, PhD Dr Charles Edelstein, Dr Cary Passik, Dr Madhav Swaminathan, Dr Jay Koyner, Dr Amit Garg, Catherine Krawczeski Christina A. de Fontnouvelle, BS, Jason H. Greenberg, MD, MHS, Heather R. Thiessen-Philbrook, MMath, Michael Zappitelli, MD, MS, Jeremy Roth, BA, Kathleen F. Kerr, PhD, Prasad Devarajan, MD, Michael Shlipak, MD, Steven Coca, DO, MS, Chirag R. Parikh, MD, PhD Dr Charles Edelstein, Dr Cary Passik, Dr Madhav Swaminathan, Dr Jay Koyner, Dr Amit Garg, Catherine Krawczeski  The Annals of Thoracic Surgery  Volume 104, Issue 6, Pages (December 2017) DOI: /j.athoracsur Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Biomarker levels by AKI status at both preoperative and postoperative timepoints by patient age group (<2 years [A, C] and ≥2 years [B, D]). Blue bars indicate no AKI, red bars indicate stage 1 AKI, and green bars indicate stage 2/3 AKI. “Early post-op time” means 0 to 6 hours postoperative, and “Late post-op” means first non-missing measurement from days 2 to 5 postoperative. Each bar encompasses interquartile range of values; lines are medians. Circles, plus-signs, and crosses are means. (AKI = acute kidney injury; IL-8 = interleukin-8; TNFα = tumor necrosis factor alpha.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Hospital stay, ICU stay, and ventilation lengths in days by biomarker tertiles. The bars indicate median number of days per biomarker tertile. (ICU = intensive care unity; IL-8 = interleukin-8; TNFα = tumor necrosis factor alpha; T = tertile.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Path analysis including the 175 children aged 2 years and older with nonmissing variable values. Arrows denote the effect of the term at the base on the term at the head. Indirect effects are blue, direct effects are orange. Estimated correlation coefficients are listed. “Standardized” means variables were standardized to have a mean of zero and SD of 1 before computing estimates. (CI = confidence interval; CPB = cardiopulmonary bypass; ΔCr = change in creatinine level; IL-8 = interleukin-8; LOV = length of ventilation.; TNFα = tumor necrosis factor alpha.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

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