1. Avoiding Opioid Overuse: Guideline-Based Management of Osteoarthritis

2. Pain in United States

3. National Pain Strategy Conclusions

4. National Pain Strategy Conclusions (cont)

5. Osteoarthritis

6. ACR Guidelines for OA

7. ACR Guidelines for OA: Pharmacologic Recommendations

8. NOT Recommended by ACR

9. ACR: No Recommendation Either Way

10. Osteoarthritis Research Society International (OARSI)

11. Opioid Use in the United States

12. NSAID Use in the United States

13. NSAID Risks

14. Mitigating Risks Associated With NSAID Use: ACR Guidelines

15. NSAIDs and Cardiovascular Risk

16. NSAIDs and Cardiovascular Risk (cont)

17. Variables Determining NSAID Risk

18. Cyclooxygenase

19. Selectivity Theory

20. CNT Collaboration

21. Major Vascular Event Risk Comparisons

22. Major Vascular Events per 1000 Patients Over a 1-Year Period

23. Summary

24. Abbreviations