1. Pharmacology of Carbamyl Inhibitors of Acetylcholinesterase
Eye
Exocrine glands
Cardiac muscle
Smooth muscles
Skeletal muscle
Toxicity 1

2. Therapeutic Uses of Inhibitors of Acetylcholinesterase
Glaucoma (wide angle)
Atony of the bladder
Atony of the gastrointestinal tract
Intoxication by antimuscarinic agents (use physostigmine)
Intoxication by tricyclic antidepressants (TCA’s) or phenothiazines (use physostigmine)
Recovery of neuromuscular function after competitive blockade of NN receptor of skeletal muscle fibers
Myasthenia gravis 2

3. Therapeutic Uses of Edrophonium
Diagnosis of myasthenia gravis
In conjunction with chosen therapeutic agent to determine proper dose of agent 3

4. Determining Proper Dose of AChE Inhibitor

5. Inhibitors of AChE Are Used for Therapy of Alzheimer’s Disease
Tacrine
Donepezil
Rivastigmine
Galantamine 5

6. Organophosphate Inhibitors of AChE6

7. Some Organophosphate Inhibitors of Acetylcholinesterase
Tetraethylpyrophosphate
Echothiophate (N+)
Diisopropylflurophosphate (DFP)
Sarin
Soman
Tabun
Malathion
Parathion
Diazinon
Chlorpyrifos
Many others 7

8. Organophosphate Inhibitors - 2
Diisopropylfluorophosphate (DFP)
Soman
Tabun
Sarin 8

9. Therapeutic use - local application to the eye for wide angle glaucoma
Echothiophate
Therapeutic use - local application to the eye for wide angle glaucoma 9

10. Conversion of Parathion to Paraoxon10

11. Conversion of Malathion to Malaoxon11