1. CHMI 2227E Biochemistry I Proteins: Secondary Structure
Beta Strands and Beta Sheets
Loops and Turns
A special case: Collagen
CHMI E.R. Gauthier, Ph.D.

2. Beta Strands and Beta Sheets
CHMI E.R. Gauthier, Ph.D.

3. Beta Sheets
CHMI E.R. Gauthier, Ph.D.

4. Hydrogen Bonded Beta StrandsC N C N C C N
CHMI E.R. Gauthier, Ph.D.

5. Antiparallel Beta Strands
CHMI E.R. Gauthier, Ph.D.

6. Parallel Beta Strands CHMI 2227 - E.R. Gauthier, Ph.D.
CHMI E.R. Gauthier, Ph.D.

7. Mixed Beta Sheets
CHMI E.R. Gauthier, Ph.D.

8. Beta Sheet Conformation
CHMI E.R. Gauthier, Ph.D.

9. Beta Pleated Sheets Beta Pleated Sheets: Silk
CHMI E.R. Gauthier, Ph.D.

10. Loops and Turns
CHMI E.R. Gauthier, Ph.D.

11. Loops and Turns
CHMI E.R. Gauthier, Ph.D.

12. Loops and Turns
CHMI E.R. Gauthier, Ph.D.

13. Beta turns CHMI 2227 - E.R. Gauthier, Ph.D.
CHMI E.R. Gauthier, Ph.D.

14. A special case : collagen
Type I
bone, tendon, fibrocartilage, dermis, cornea
Type II
nucleus pulposus, hyaline cartilage
Type III
intestinal and uterine wall
Type IV
endothelial, epithelial membranes
Type V*
cornea, placenta, bone, heart valve
* Found in small quantities
CHMI E.R. Gauthier, Ph.D.

15. A special case : collagen
Chain 1
Chain 2
Chain 3
(from Kadler, 1996)
Triple helix
CHMI E.R. Gauthier, Ph.D.

16. A special case : collagen
Hypro
5-Hylys
CHMI E.R. Gauthier, Ph.D.

17. A special case : collagen13
CHMI E.R. Gauthier, Ph.D.

18. A special case : collagen
CHMI E.R. Gauthier, Ph.D.

19. Hydrogen bonds stabilize the collagen triple helix
Gly of Chain 1
Pro of Chain 2 G
Glycine
Hypro
Pro
CHMI E.R. Gauthier, Ph.D.

20. Formation of collagen fibers
Collagen triple helix
(tropocollagen)
Lysine
CHMI E.R. Gauthier, Ph.D.

21. Formation of collagen fibers
Transmission electron
microscopy of collagen
fibers
CHMI E.R. Gauthier, Ph.D.

22. Collagen, Vitamin C and scurvy
CHMI E.R. Gauthier, Ph.D.