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CHMI 2227E Biochemistry I Proteins: Secondary Structure
Beta Strands and Beta Sheets Loops and Turns A special case: Collagen CHMI E.R. Gauthier, Ph.D.
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Beta Strands and Beta Sheets
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Beta Sheets CHMI E.R. Gauthier, Ph.D.
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Hydrogen Bonded Beta Strands
C N C N C C N CHMI E.R. Gauthier, Ph.D.
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Antiparallel Beta Strands
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Parallel Beta Strands CHMI 2227 - E.R. Gauthier, Ph.D.
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Mixed Beta Sheets CHMI E.R. Gauthier, Ph.D.
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Beta Sheet Conformation
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Beta Pleated Sheets Beta Pleated Sheets: Silk
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Loops and Turns CHMI E.R. Gauthier, Ph.D.
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Loops and Turns CHMI E.R. Gauthier, Ph.D.
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Loops and Turns CHMI E.R. Gauthier, Ph.D.
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Beta turns CHMI 2227 - E.R. Gauthier, Ph.D.
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A special case : collagen
Type I bone, tendon, fibrocartilage, dermis, cornea Type II nucleus pulposus, hyaline cartilage Type III intestinal and uterine wall Type IV endothelial, epithelial membranes Type V* cornea, placenta, bone, heart valve * Found in small quantities CHMI E.R. Gauthier, Ph.D.
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A special case : collagen
Chain 1 Chain 2 Chain 3 (from Kadler, 1996) Triple helix CHMI E.R. Gauthier, Ph.D.
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A special case : collagen
Hypro 5-Hylys CHMI E.R. Gauthier, Ph.D.
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A special case : collagen
13 CHMI E.R. Gauthier, Ph.D.
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A special case : collagen
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Hydrogen bonds stabilize the collagen triple helix
Gly of Chain 1 Pro of Chain 2 G Glycine Hypro Pro CHMI E.R. Gauthier, Ph.D.
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Formation of collagen fibers
Collagen triple helix (tropocollagen) Lysine CHMI E.R. Gauthier, Ph.D.
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Formation of collagen fibers
Transmission electron microscopy of collagen fibers CHMI E.R. Gauthier, Ph.D.
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Collagen, Vitamin C and scurvy
CHMI E.R. Gauthier, Ph.D.
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