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Enhanced synergy between fluticasone propionate and salmeterol inhaled from a single inhaler versus separate inhalers  Harold S. Nelson, MDa, Kenneth.

Published byBruno Jean-Pierre St-Amand Modified over 6 years ago

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Presentation on theme: "Enhanced synergy between fluticasone propionate and salmeterol inhaled from a single inhaler versus separate inhalers  Harold S. Nelson, MDa, Kenneth."— Presentation transcript:

1 Enhanced synergy between fluticasone propionate and salmeterol inhaled from a single inhaler versus separate inhalers  Harold S. Nelson, MDa, Kenneth R. Chapman, FACPb, Stephen D. Pyke, MScc, Malcolm Johnson, PhDc, John N. Pritchard, PhDc  Journal of Allergy and Clinical Immunology  Volume 112, Issue 1, Pages (July 2003) DOI: /mai Copyright © 2003 Mosby, Inc. Terms and Conditions

2 Fig. 1 A, Difference in change in mean morning PEF (amPEF) over weeks 1 to 12 between ITT results (fixed-effects model). B, Mean change in clinic FEV1 at week 12 (ITT results). Journal of Allergy and Clinical Immunology  , 29-36DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

3 Fig. 2 A, Odds of achieving a greater than 15 L/min improvement in mean morning PEF (amPEF) with combination therapy compared with concurrent therapy (ITT results). B, Odds of achieving a greater than 30 L/min improvement in morning PEF with combination therapy compared with concurrent therapy (ITT results). Journal of Allergy and Clinical Immunology  , 29-36DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

4 Fig. 3 Raman laser analysis of Seretide metered-dose inhaler formulation on stage 4 of an Anderson Cascade Impactor showing particles of fluticasone propionate (green) , salmeterol (red) , and coassociation of both fluticasone propionate and salmeterol (yellow) . Journal of Allergy and Clinical Immunology  , 29-36DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

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