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Endometriosis and ovarian cancer: potential benefits and harms of screening and risk- reducing surgery Sun-Wei Guo, M.Med., Ph.D. Fertility and Sterility Volume 104, Issue 4, Pages (October 2015) DOI: /j.fertnstert Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions
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Figure 1 Scatter plots showing the relationship between the prevalence of endometriosis in OVCA of all histotypes (A), in patients with serous tumors (B), mucinous tumors (C), clear cell tumors (D), endometroid tumors (E), and clear cell and endometroid tumors combined (F), and the measure of precision (either log- or square-root-transformed sample size). The alpha-numeric combinations are the IDs shown in Table 1, and each ID represents one study. In A, E, and F, the dashed line is the linear regression line, and the number is the Pearson's correlation coefficient. *P<.05; **P<.01; ***P<.001. CC = clear cell; E = endometrioid. Fertility and Sterility , DOI: ( /j.fertnstert ) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions
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Figure 2 (A) Funnel plot for the log RRs, using data extracted from Table 2. The dashed line represents RR = The alpha-numeric combinations are the IDs shown in Table 2, and each ID represents one study. The IDs shown in red are those studies devoted exclusively to the endometriosis–OVCA association, whereas those in blue are studies focusing on other risk factors. (B) Funnel plot for the log SIRs, using data extracted from Table 3. The dashed line represents SIR = 1.797, as provided in reference 51. Fertility and Sterility , DOI: ( /j.fertnstert ) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions
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Figure 3 A graphic rendition of the sensitivity analysis for the association of endometriosis and risk of invasive OVCA, based on timing (time interval) of diagnosis between the two diseases, as reported by Pearce et al. (87) (their Table 4). When patients with endometriosis and OVCA diagnosed (Dx) within the time interval ≤3 years, 5 years, and 10 years are excluded, the decrease in the OR estimate is seen. Fertility and Sterility , DOI: ( /j.fertnstert ) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions
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Figure 4 (A) Diagram showing various features of endometriosis. The phrases in blue are features manifested at the organismic level, whereas those in other colors are features manifested at the cellular and molecular levels. The phrases in red are features that are comparable with, but not necessarily identical to, certain hallmarks of cancer as elaborated in reference 66. (B) The comparison of molecular circuitry in endometriosis and cancer. Although endometriotic lesions may appear to have sets of circuitry similar to that of cancer, the components (genes and their products) and the wiring (signaling networks) of these circuitries may be different, and this is shown in different shades of color. More importantly, the DNA-damage sensors in endometriosis appear to be intact, but show dysfunction in cancer. Fertility and Sterility , DOI: ( /j.fertnstert ) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions
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