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Volume 127, Issue 6, Pages (December 2004)

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Presentation on theme: "Volume 127, Issue 6, Pages (December 2004)"— Presentation transcript:

1 Volume 127, Issue 6, Pages 1733-1738 (December 2004)
Clinical relevance of hepatitis B virus genotype in children with chronic infection and hepatocellular carcinoma  Yen-Hsuan Ni, Mei-Hwei Chang, Kuan-Jan Wang, Hong-Yuan Hsu, Huey-Ling Chen, Jia-Horng Kao, Shiou-Hwei Yeh, Yung-Ming Jeng, Keh-Sung Tsai, Ding-Shinn Chen  Gastroenterology  Volume 127, Issue 6, Pages (December 2004) DOI: /j.gastro Copyright © 2004 American Gastroenterological Association Terms and Conditions

2 Figure 1 Genotype distribution in the 3 groups of chronic HBV-infected children and children with HCC. HBeAg(+/+) group: persistent HBeAg seropositive; HBeAg(+/−) group: underwent HBeAg seroconversion during follow-up evaluation; anti-HBe(+) group: already anti-HBe positive at enrollment, and HCC children. Serum HBV-DNA levels could not be detected by PCR in 7 HCC children. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2004 American Gastroenterological Association Terms and Conditions

3 Figure 2 Children positive for HBeAg were analyzed according to their HBV genotypes. Those with genotype C had a significant delay of HBeAg seroconversion as compared with genotype B in terms of their age of seroconversion (Kaplan–Meier survival curve, P < .0001). Cases with genotype changes and mixed genotypes were excluded from the analysis. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2004 American Gastroenterological Association Terms and Conditions


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