1. Low DEFB4 Copy Number and High Systemic hBD-2 and IL-22 Levels Are Associated with Dermatophytosis 
Sameh W. Jaradat, Susana Cubillos, Nadine Krieg, Katja Lehmann, Bassam Issa, Susann Piehler, Sylvi Wehner-Diab, Uta-Christina Hipler, Johannes Norgauer 
Journal of Investigative Dermatology 
Volume 135, Issue 3, Pages (March 2015)
DOI: /jid
Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions

2. Figure 1
Frequency distribution of beta defensin 2 (DEFB4) copy number (CN) variation. Values are for controls (n=195) and (a) the combined group of dermatophytosis patients (n=247), and patients with tinea (b) corporis (n=59), (c) cruris (n=24), (d) pedis (n=61), and (e) unguium (n=64), as well as (f) with multiple lesions (n=39). CN was rounded to the nearest integer assigned to bins of <4, equal to 4, and >4, and the final value was one that was the same in two assays. Odds ratios (ORs) and confidence intervals (CIs) were calculated for cases with >4 CN versus ∑ cases with ⩽4 CN. P<0.05 was significant (Bonferroni-corrected P values).
Journal of Investigative Dermatology  , DOI: ( /jid )
Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions

3. Figure 2
Serum levels of human beta defensin (hBD)-2 and interleukin (IL)-22 in dermatophytosis patients (n=247) and healthy controls (n=195). (a) Human beta defensin (hBD)-2; (b) interleukin (IL)-22. Patient subgroups are represented by different colors. The medians are indicated by horizontal bars. Comparisons between patient subgroups and the control group were performed with the Mann–Whitney test, and comparisons between subgroups were performed with the Kruskal–Wallis test. P<0.05 was significant (Bonferroni-corrected P values).
Journal of Investigative Dermatology  , DOI: ( /jid )
Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions

4. Figure 3
Correlation between beta defensin 2 (DEFB4) copy number (CN) variation and serum human beta defensin (hBD)-2 and interleukin (IL)-22 levels. Dermatophytosis patient subgroups are represented by different colors. (a) DEFB4 CN was positively correlated with hBD-2 level in controls (n=195) but not in patients (n=247), and (b) negatively correlated with IL-22 level in patients but not in controls. (c) Serum hBD-2 and IL-22 levels were positively correlated in patients but not in controls. Spearman’s rank correlation test was used to assess correlation. P<0.05 was considered significant (Bonferroni-corrected P values).
Journal of Investigative Dermatology  , DOI: ( /jid )
Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions

5. Figure 4
Process of dermatophytosis study subject recruitment and assessment.
Journal of Investigative Dermatology  , DOI: ( /jid )
Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions