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The Distinct Roles of JAM-A in Reovirus Pathogenesis

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Presentation on theme: "The Distinct Roles of JAM-A in Reovirus Pathogenesis"— Presentation transcript:

1 The Distinct Roles of JAM-A in Reovirus Pathogenesis
Carolyn B. Coyne  Cell Host & Microbe  Volume 5, Issue 1, Pages 3-5 (January 2009) DOI: /j.chom Copyright © 2009 Elsevier Inc. Terms and Conditions

2 Figure 1 Models for the Role of JAM-A in Facilitating Reovirus Hematogenous Dissemination (A–C) The lining of the microvasculature is composed of a sheet of polarized endothelial cells that separate the bloodstream from the underlying tissue. JAM-A may mediate the hematogenous dissemination of reovirus by a number of mechanisms that may include (A) the facilitation of leukocyte transmigration across the endothelium, (B) the transcytosis and/or endocytosis of reovirus particles, and/or (C) the disassociation of JAM-JAM dimerization to allow for reovirus escape into the bloodstream. These possible mechanisms may exist in parallel or in some combination. Cell Host & Microbe 2009 5, 3-5DOI: ( /j.chom ) Copyright © 2009 Elsevier Inc. Terms and Conditions

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