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Association of IL-8 and MCP-1 with the development of reexpansion pulmonary edema in rabbits  Yukinori Sakao, MD, Osamu Kajikawa, PhD, Thomas R Martin,

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Presentation on theme: "Association of IL-8 and MCP-1 with the development of reexpansion pulmonary edema in rabbits  Yukinori Sakao, MD, Osamu Kajikawa, PhD, Thomas R Martin,"— Presentation transcript:

1 Association of IL-8 and MCP-1 with the development of reexpansion pulmonary edema in rabbits 
Yukinori Sakao, MD, Osamu Kajikawa, PhD, Thomas R Martin, MD, Yoshiaki Nakahara, MD, Will A Hadden, DVM, Cynde L Harmon, Edmund J Miller, PhD  The Annals of Thoracic Surgery  Volume 71, Issue 6, Pages (June 2001) DOI: /S (01)

2 Fig 1 Roentgenogram examination showed (A) the collapse of the lung and (B) reexpansion just after removal of the bag followed by evacuation. The Annals of Thoracic Surgery  , DOI: ( /S (01) )

3 Fig 2 The blood gas analysis comparison between the reexpansion and control groups. (Base = blood sampled before anesthesia on the 7th day as base line. Closed circles = the reexpansion group (N = 5). Open circles = the control group (N = 6).) Values are mean ± standard error. ∗p < 0.05, when compared with the control group. The Annals of Thoracic Surgery  , DOI: ( /S (01) )

4 Fig 3 β-Glucuronidase concentration in the BALF comparison between the reexpansion (N = 5) and control (N = 6) groups. Values are mean ± standard error. The right lung is the reexpanded lung in the reexpansion group, and is the collapsed lung without reexpansion in the control group. The BALF in each group was sampled 3 hours after placement of the chest drainage tube. ∗∗p < 0.01, when compared with the control group. The Annals of Thoracic Surgery  , DOI: ( /S (01) )

5 Fig 4 Evans blue dye concentration in the BALF comparison between the reexpansion (N = 5) and control (N = 6) groups. Values are mean ± standard error. The right lung is the reexpanded lung in the reexpansion group, and is the collapsed lung without reexpansion in the control group. The BALF in each group was sampled 3 hours after placement of the chest drainage tube. ∗p < 0.05, ∗∗p < 0.01, when compared with the control group. The Annals of Thoracic Surgery  , DOI: ( /S (01) )

6 Fig 5 Cytokines in BALF comparison between the reexpansion (N = 5) and control (N = 6) groups. (A) IL-8 concentration in the BALF, and (B) MCP-1 concentration in the BALF. Values are mean ± standard error. The BALF in each group was sampled 3 hours after placement of the chest drainage tube. ∗∗p < 0.01, ∗∗∗p < 0.005, when compared with the control group. The Annals of Thoracic Surgery  , DOI: ( /S (01) )


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