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In the Limelight: Ras, Ebola, Deubiquitinase, and Acetyl-CoA

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Presentation on theme: "In the Limelight: Ras, Ebola, Deubiquitinase, and Acetyl-CoA"— Presentation transcript:

1 In the Limelight: Ras, Ebola, Deubiquitinase, and Acetyl-CoA
Chemistry & Biology  Volume 21, Issue 3, Pages (March 2014) DOI: /j.chembiol Copyright © Terms and Conditions

2 Small-molecule modulators of SOS (light blue) are found to bind a hydrophobic cavity located close to the region of Ras (orange) involved in interactions with the SOS catalytic domain (gray). Image courtesy of S. Fesik. Chemistry & Biology  , DOI: ( /j.chembiol ) Copyright © Terms and Conditions

3 Small-molecule chemical probe, ML323, binds and inhibits the USP1:UAF1 deubiquitinase complex, leading to insights about the connection between deubiquitination and two DNA damage response pathways; Fanconi anemia (FA) and DNA translesion synthesis (TLS). Image courtesy of Z. Zhuang and D. Maloney. Chemistry & Biology  , DOI: ( /j.chembiol ) Copyright © Terms and Conditions


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