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George-Lucian Moldovan, Alan D. D'Andrea  Cancer Cell 

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Presentation on theme: "George-Lucian Moldovan, Alan D. D'Andrea  Cancer Cell "— Presentation transcript:

1 To the Rescue: The Fanconi Anemia Genome Stability Pathway Salvages Replication Forks 
George-Lucian Moldovan, Alan D. D'Andrea  Cancer Cell  Volume 22, Issue 1, Pages 5-6 (July 2012) DOI: /j.ccr Copyright © 2012 Elsevier Inc. Terms and Conditions

2 Figure 1 The Fanconi Anemia Pathway and BRCA2 Cooperate to Promote the Stability of Stalled Replication Forks (A) FA proteins and BRCA2 protect stalled replication forks against degradation by stabilizing RAD51 filaments. (B) In the absence of the FA/BRCA pathway, the MRE11 nuclease degrades stalled replication forks, promoting genomic instability. (C) Fork protection in FA/BRCA pathway mutants can be rescued by stabilizing RAD51 filaments. RAD51 is represented by red dots. Cancer Cell  , 5-6DOI: ( /j.ccr ) Copyright © 2012 Elsevier Inc. Terms and Conditions

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