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Genetic variants associated with female reproductive ageing – potential markers for assessing ovarian function and ovarian stimulation outcome Triin Laisk-Podar, Tanel Kaart, Maire Peters, Andres Salumets Reproductive BioMedicine Online Volume 31, Issue 2, Pages (August 2015) DOI: /j.rbmo Copyright © 2015 Reproductive Healthcare Ltd. Terms and Conditions
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Figure 1 Effect of studied genotypes on analysed traits. Least square means (±standard error) or estimated probabilities (± standard error) of studied parameters for SNP genotypes with statistically significant effect (model details in Supplementary Table S2 and least square means/estimated probabilities for all genotypes in Supplementary Table S3). (A) Early follicular phase follicle stimulating hormone (FSH) concentrations according to rs (FNDC4) and rs (FSHB) genotypes; (B) mean early antral follicle count according to rs (FSHR) and rs6166 (FSHR) genotypes; (C) total amount of rFSH used according to rs (intergenic), rs (NLRP11) and rs (RHBDL2) genotypes; (D) amount of recombinant FSH (rFSH) administered per retrieved oocyte according to rs (TMEM150B), rs (SYCP2L) and rs (RHBDL2) genotypes; (E) number of ovarian follicles punctured according to rs (KPNA3), rs (TDRD3), rs (METAP1D) and rs (FSHR) genotypes; (F) number of obtained oocytes according to rs (TDRD3) and rs (METAP1D) genotypes; (G) probability of biochemical pregnancy according to rs (SYCP2L) and rs (intergenic) genotypes; and (H) probability of clinical pregnancy according to rs (intergenic), rs (SYCP2L), rs (RHBDL2) and rs (FSHB) genotypes. Reproductive BioMedicine Online , DOI: ( /j.rbmo ) Copyright © 2015 Reproductive Healthcare Ltd. Terms and Conditions
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Figure 2 Schematic overview of the current results. Effect estimates given for allele shown in brackets. For SNP from the menopause meta-analysis, the influence on the timing of natural menopause is also shown (as derived from Table 1 of the paper by Stolk et al., 2012). Reproductive BioMedicine Online , DOI: ( /j.rbmo ) Copyright © 2015 Reproductive Healthcare Ltd. Terms and Conditions
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