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Inflammation and Chronic Prostatic Diseases: Evidence for a Link?

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Presentation on theme: "Inflammation and Chronic Prostatic Diseases: Evidence for a Link?"— Presentation transcript:

1 Inflammation and Chronic Prostatic Diseases: Evidence for a Link?
Alessandro Sciarra, Franco Di Silverio, Stefano Salciccia, Ana Maria Autran Gomez, Alessandro Gentilucci, Vincenzo Gentile  European Urology  Volume 52, Issue 4, Pages (October 2007) DOI: /j.eururo Copyright © 2007 European Association of Urology Terms and Conditions

2 Fig. 1 Increased apoptotic activity in human benign prostatic hyperplasia tissue using a cyclooxygenase-2 inhibitor. Immunohistochemical analysis [25]. Arrows indicate increased apoptotic activity at epithelial cells level (TdT-mediated dUTP nick-end labeling method). European Urology  , DOI: ( /j.eururo ) Copyright © 2007 European Association of Urology Terms and Conditions

3 Fig. 2 Inflammation and prostate growth: a possible pathogenetic mechanism. Role of oxidative stress by oxidant electrophiles, nitric oxide and cyclooxygenase activity; protective role of glutathione-S-transferase. European Urology  , DOI: ( /j.eururo ) Copyright © 2007 European Association of Urology Terms and Conditions

4 Fig. 3 Possible event cascade for prostate cancer: inflammation as early event, proliferative inflammatory atrophy (PIA), prostatic intraepithelial neoplasia (PIN), and prostate cancer. Role of oxidants, nitric oxide, and cyclooxygenase-2 activities in the transition from inflammation and PIA. Role of glutathione-S-transferase–P1 methylation and inactivation in the transition from PIA to high-grade PIN and therefore to prostate cancer. European Urology  , DOI: ( /j.eururo ) Copyright © 2007 European Association of Urology Terms and Conditions


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