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Published byHector Bradley Modified over 6 years ago
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Figure 3 Lineage tracing of resident cardiac fibroblasts
Figure 3 | Lineage tracing of resident cardiac fibroblasts. Hearts from adult Tcf21mCrem mice containing a Cre-dependent ROSA26TdT indicator that was induced with tamoxifen perinatally. Tissue-resident fibroblasts are labelled red. Mice were subjected to either a | a sham surgical procedure (no injury) or b | 6 weeks of a thoracic aortic constriction surgical procedure before harvesting. The images show that Tcf21-lineage tissue-resident fibroblasts are uniformly distributed throughout the heart and that they expand with pressure-overload stimulation. Tallquist, M. D. & Molkentin, J. D. (2017) Redefining the identity of cardiac fibroblasts Nat. Rev. Cardiol. doi: /nrcardio
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