1. fackrel@Uwindsor.ca Corona.ppt
Corona Viruses
Corona.ppt

2. Corona Viruses Structure Classification Multiplication
Clinical manifestations
Epidemiology
Diagnosis
Control
Baron’s Web Site

3. Structure Spherical or pleomorphic 80-100 nm Enveloped
club shaped glycoprotein spikes
ss RNA sense strand

5. Classification OC43 like 229E like Crown of envelope glycoproteins
2 serotypes
OC43 like
229E like

6. Multiplication Virus enters nasal epithelium Uncoats
ssRNA transcribed >>> translated
mRNA nested set
common 3’ ends
only unique portion of 5’ translated

7. Clinical Manifestations
Common Cold
mild, acute
upper respiratory
tract infections
Diarrhea in children
RARE!

8. Corona Virus Pathogenesis
coryza
Nasal Secretions
Nasopharynx
Time (days)
Virus
DISEASE
Interferon
antibody

9. Epidemiology local epidemics Peak incidence in Winter
last few weeks- months

10. Diagnosis Clinically undistinguished from other colds Laboratory
increase in antibody titre over time
virus difficult to isolate

11. Control Treat symptoms Improve hygiene No vaccines
No specific antivirals

12. DONE!!!