1. Nat. Rev. Nephrol. doi:10.1038/nrneph.2017.16
Figure 4 Management and therapeutic strategies for non-alcoholic fatty liver disease (NAFLD)
Figure 4 | Management and therapeutic strategies for non-alcoholic fatty liver disease (NAFLD). The current treatment strategy for NAFLD applies a stepwise approach. The first approach is the treatment of overweight and obese patients through appropriate changes in lifestyle or, in cases of severe obesity, bariatric surgery. This step is followed by the optimization of glycaemic control in patients with established diabetes mellitus and the treatment of all coexisting cardiometabolic risk factors, which might be accompanied by the use of therapies that potentially have beneficial effects on the liver. The main goals of treatment are threefold: to improve hepatic/peripheral insulin sensitivity; to reduce intra-hepatic fat infiltration; and to avoid the progression of nonalcoholic steatohepatitis to more severe histological forms (cirrhosis, liver failure and hepatocellular carcinoma (HCC)), which will require management/treatment in their own right.
Targher, G. & Byrne, C. D. (2017) Non-alcoholic fatty liver disease: an emerging driving force in chronic kidney disease
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