1. Nat. Rev. Neurol. doi:10.1038/nrneurol.2017.129
Figure 3 The three main pathophysiological profiles in patients with acute stroke as shown by 15O-PET
Figure 3 | The three main pathophysiological profiles in patients with acute stroke as shown by 15O-PET. The region of reduced cerebral blood flow (CBF) but relatively preserved cerebral metabolic rate of oxygen consumption (CMRO2) in the 'target mismatch' group represents potentially salvageable penumbra suitable for acute reperfusion therapy (infarct core shown by white arrows). The extensive reduction in both CBF and CMRO2 in the 'large core' group is associated with a poor prognosis. By contrast, hyperperfusion with a small area of reduced CMRO2 indicates spontaneous reperfusion in the 'no mismatch' group, which is associated with a favourable prognosis. Oxygen extraction fraction (OEF) reflects the mismatch between CBF and CMRO2, which is most prominent in the 'target mismatch' group (in whom OEF rises and CBF falls, but CMRO2 remains relatively unaffected). Figure reproduced with permission from Oxford University Press, Ref. 74.
Figure reproduced with permission from Oxford University Press, Agarwal, S., Warburton, E. A. & Baron, J. C. From time is brain to physiology is brain: a case for reflection in acute stroke treatment decisions. Brain 138, 1768–1770 (2015).
Evans, N. R. et al. (2017) PET imaging of the neurovascular interface in cerebrovascular disease
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