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Novel Basal Insulin Formulations in the Modern Era of T2D Management

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Presentation on theme: "Novel Basal Insulin Formulations in the Modern Era of T2D Management"— Presentation transcript:

1 Novel Basal Insulin Formulations in the Modern Era of T2D Management

2

3 PK/PD Assessment of Insulin Analogs

4 Intrasubject Variability With NPH Insulin (As Measured by GIR)

5 Basal Insulins Are Not Equivalent

6 Insulin PD Affected by BMI

7 PD of Degludec U100 at Steady State*

8 PD of Glargine U100 With Different Doses

9 PD of Regular Human Insulin U500 and U100*

10 PD of Degludec U100 and U200*

11 PD of Glargine U100 vs U300*

12 What Does All This Mean?

13 Insulin Glargine U300

14 EDITION 2: Glargine U300 vs U100*

15 EDITION Pooled Analysis

16 Insulin Degludec

17 Degludec vs Glargine U100: Insulin-Naive Patients* at 1 Y

18 Degludec vs Glargine U100*: Basal-Bolus With Prandial Insulin Aspart

19 Degludec Variable Dosing† vs Glargine U100 or Degludec Dosed Regularly*

20 New Insulin Pens

21 New Data at ADA 2016

22 Discussion: Use of Basal Insulin Analogs in T2D

23 Discussion: Considerations for Selecting or Switching Basal Insulin Analogs

24 Discussion: Other Considerations

25 Concluding Remarks

26 Abbreviations


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