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Kai Ihnken, MD, Kiyozo Morita, MD, Gerald D Buckberg, MD 

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Presentation on theme: "Kai Ihnken, MD, Kiyozo Morita, MD, Gerald D Buckberg, MD "— Presentation transcript:

1 Delayed cardioplegic reoxygenation reduces reoxygenation injury in cyanotic immature hearts 
Kai Ihnken, MD, Kiyozo Morita, MD, Gerald D Buckberg, MD  The Annals of Thoracic Surgery  Volume 66, Issue 1, Pages (July 1998) DOI: /S (98)

2 Fig 1 Postbypass myocardial contractility expressed as percentage of recovery of end-systolic elastance. (Control = animals undergoing cardiopulmonary bypass without hypoxemia or cardioplegic arrest; No Hypoxemia = piglets undergoing cardioplegic arrest on cardiopulmonary bypass without hypoxemia; NoRx = hypoxemic animals undergoing reoxygenation on cardiopulmonary bypass including cardioplegic arrest; Rx = hypoxemic piglets treated with delayed reoxygenation; ∗ = p < 0.05 versus Control and No Hypoxemia; ∗∗ = p < 0.05 versus NoRx. The Annals of Thoracic Surgery  , DOI: ( /S (98) )

3 Fig 2 Antioxidant reserve capacity. Vulnerability of hypoxemic and reoxygenated myocardium to subsequent oxidant stress is determined by exposing cardiac homogenates to 0 to 4 mmol/L t-butylhydroperoxide. (MDA = malondialdehyde; Control [closed triangles] = animals undergoing cardiopulmonary bypass without hypoxemia or cardioplegic arrest; No hypoxemia [open circles] = piglets undergoing cardioplegic arrest on cardiopulmonary bypass without hypoxemia; NoRx [closed circles] = hypoxemic animals undergoing reoxygenation on cardiopulmonary bypass including cardioplegic arrest; Rx [open triangles] = hypoxemic piglets treated with delayed reoxygenation; ∗ = p < 0.05 versus all other groups.) The Annals of Thoracic Surgery  , DOI: ( /S (98) )

4 Fig 3 Myocardial conjugated diene (CD) production (as a marker of lipid peroxidation) during cardioplegic induction. (No hypoxemia = piglets undergoing cardioplegic arrest on CPB without hypoxemia; NoRx = hypoxemic animals undergoing reoxygenation on CPB including cardioplegic arrest; Rx = hypoxemic piglets treated with delayed reoxygenation; ∗ = p < 0.05 versus NoRx.) The Annals of Thoracic Surgery  , DOI: ( /S (98) )

5 Fig 4 Plasma conjugated diene levels from coronary sinus blood. (BCP = blood cardioplegic arrest; Control [closed squares] = animals undergoing cardiopulmonary bypass [CPB] without hypoxemia or cardioplegic arrest; No hypoxemia [open triangles] = piglets undergoing cardioplegic arrest on CPB without hypoxemia; NoRx [closed circles] = hypoxemic animals undergoing reoxygenation on CPB including cardioplegic arrest; Rx [open circles] = hypoxemic piglets treated with delayed reoxygenation; ∗ = p < 0.05 versus all other groups.) The Annals of Thoracic Surgery  , DOI: ( /S (98) )

6 Fig 5 Myocardial oxygen consumption (O2) during cardioplegic induction. (No hypoxemia [open circles] = piglets undergoing cardioplegic arrest on cardiopulmonary bypass without hypoxemia; NoRx [closed circles] = hypoxemic animals undergoing reoxygenation on cardiopulmonary bypass including cardioplegic arrest; Rx [open triangles] = hypoxemic piglets treated with delayed reoxygenation; ∗ = p < 0.05 versus No hypoxemia; ∗∗ = p < 0.05 versus NoRx.) The Annals of Thoracic Surgery  , DOI: ( /S (98) )

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