1. Multiple Sclerosis Rare disease < 200,000 cases per year
Autoimmune disease affecting myelin
Familial history increases risk (HLA)
Caucasian highest risk
Females ~twice as likely affected
No cure
Symptomatic treatments (e.g. corticosteroids)
Modify progression (Capaxone)

2. <5%
<1%
10%
85%

5. Team Workshop 1:Use the ExAC database to explore exome variants in the HLA-DRB1 gene. List variants that could affect peptide binding (

9. Team Workshop 2: Use the Clinical Trials Website to explore current RRMS drugs in clinical trials. Choose a trial with results and list the drug, the sponsor and the cohort number ( )

10. Team Workshop 3: Choose 2 of the drugs from Workshop 2 and determine the mechanism of action (MOA) using drugbank

11. Remember Before 12 PM of the next class day:
go to b.socrative.com/student/login and complete the quiz