1. Why this pesky enzyme is widening your waistline!
11bHSD1:
Why this pesky enzyme is widening your waistline!
By: Carrie Jones, ND, MPH

2. Disclosures: Medical Director of Precision Analytical, Inc.
Copyright 2017: Carrie Jones, ND, MPH

3. Copyright 2017: Carrie Jones, ND, MPH

4. What is the (simplified) stress response?
Copyright 2017: Carrie Jones, ND, MPH

5. 11-Beta hydroxysteroid dehydrogenase
Copyright 2017: Carrie Jones, ND, MPH

6. Where is 11bHSD1 most prevalent?
Copyright 2017: Carrie Jones, ND, MPH

7. Where is 11bHSD2 most prevalent?
Copyright 2017: Carrie Jones, ND, MPH

8. It’s a balance, right?
Copyright 2017: Carrie Jones, ND, MPH

9. This is a fat cell
Copyright 2017: Carrie Jones, ND, MPH

10. In the fat cell… Cortisone Cortisol 11bHSD1
Even when cortisol everywhere else in the body is ‘in balance’ it can get amplified in fat cells 
Copyright 2017: Carrie Jones, ND, MPH

11. The Result?
Copyright 2017: Carrie Jones, ND, MPH

12. How do I test 11bHSD activity?
Research says you have to look at urinary cortisol and cortisone metabolites
THF (cortisol) to THE (cortisone) ratio
Copyright 2017: Carrie Jones, ND, MPH

13. Testing: ↑Total cortisol production/metabolism
Prefers cortisol systemically due to 11bHSD1
Copyright 2017: Carrie Jones, ND, MPH

14. Increases 11bHSD1 Genetics Inflammation Insulin Obesity itself 
Thyroid dysfunction
Licorice supplementation
Glucocorticoid use
Copyright 2017: Carrie Jones, ND, MPH

15. Treatment goals!
Copyright 2017: Carrie Jones, ND, MPH

16. Consider:
Address the inflammation, thyroid, insulin, hormones, licorice supplementation or medication
Flavonoids
Magnolia
EGCG
Zizyphus vulgaris
Scutellaria baicalensis
Ocinum sanctum
Healthy bile acid
Copyright 2017: Carrie Jones, ND, MPH

17. Thank you for listening!
Copyright 2017: Carrie Jones, ND, MPH