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Detection of BRAF V600 Mutations in Metastatic Melanoma

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Presentation on theme: "Detection of BRAF V600 Mutations in Metastatic Melanoma"— Presentation transcript:

1 Detection of BRAF V600 Mutations in Metastatic Melanoma
Kevin Qu, Qiulu Pan, Xi Zhang, Luis Rodriguez, Ke Zhang, Hairong Li, Albert Ho, Heather Sanders, Anthony Sferruzza, Shih-Min Cheng, Diedre Nguyen, Dan Jones, Frederic Waldman  The Journal of Molecular Diagnostics  Volume 15, Issue 6, Pages (November 2013) DOI: /j.jmoldx Copyright © 2013 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

2 Figure 1 Sequencing amplification plots of BRAF codon 600. (A) V600 codon showing the wild-type GTG sequence. (B) V600E codon resulting from a single-nucleotide mutation (GTG>GAG). (C) V600E codon resulting from a dinucleotide mutation (GTG>GAA). (D) V600K codon resulting from a dinucleotide mutation (GTG>AAG). The top of each panel shows the sequence in the forward direction and the bottom portion shows the sequence in the reverse direction. The Journal of Molecular Diagnostics  , DOI: ( /j.jmoldx ) Copyright © 2013 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

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