1. Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance
by Angela L. Rasmussen, Atsushi Okumura, Martin T. Ferris, Richard Green, Friederike Feldmann, Sara M. Kelly, Dana P. Scott, David Safronetz, Elaine Haddock, Rachel LaCasse, Matthew J. Thomas, Pavel Sova, Victoria S. Carter, Jeffrey M. Weiss, Darla R. Miller, Ginger D. Shaw, Marcus J. Korth, Mark T. Heise, Ralph S. Baric, Fernando Pardo-Manuel de Villena, Heinz Feldmann, and Michael G. Katze
Science
Volume 346(6212):
November 21, 2014
Published by AAAS

2. Fig. 1 Distinct morbidity and mortality after MA-EBOV infection in CC-RIX mouse lines.
Distinct morbidity and mortality after MA-EBOV infection in CC-RIX mouse lines. (A) Percent of starting body weight over the course of infection in susceptible (red squares) and resistant (blue circles) mice. Data shown are mean ± SEM from five mice per CC-RIX line. (B) Kaplan-Meier survival curve for susceptible (red) and resistant (blue) mice. Five mice were used for each CC-RIX line. (C to F) Gross appearance of liver at necropsy in uninfected susceptible (C) and resistant (E) mice and on day 5 p.i. in susceptible (D) and resistant (F) mice.
Angela L. Rasmussen et al. Science 2014;346:
Published by AAAS

3. Fig. 2 MA-EBOV replication in CC-RIX mouse lines.
MA-EBOV replication in CC-RIX mouse lines. (A and B) Quantitative real-time polymerase chain reaction showing the expression of MA-EBOV genomes relative to mouse 18S ribosomal RNA in spleen (A) and liver (B). Data shown are mean ± SEM for three mice per time point per RIX line. (C and D) Titration of infectious MA-EBOV in organ homogenates from spleen (C) and liver (D) quantified as FFUs per milliliter. No infectious virus was detected before day 3 p.i. Data shown are mean ± SEM from two experiments using two or three mice per time point per CC-RIX line. (E to H) Immunohistochemical staining for VP40 in resistant liver [(E) and (F)] and susceptible liver [(G) and (H)]. The arrows indicate representative hepatocyte morphology (t test, *P < 0.05).
Angela L. Rasmussen et al. Science 2014;346:
Published by AAAS

4. Fig. 3 Quantification of coagulopathy and hemorrhage in CC-RIX mouse lines.
Quantification of coagulopathy and hemorrhage in CC-RIX mouse lines. (A to C) Coagulation times in seconds for thrombin (A), prothrombin (B), and activated partial thromboplastin (C) over the course of MA-EBOV infection. (D) Serum fibrinogen levels in CC-RIX mice over the course of MA-EBOV infection. All data shown are the mean ± SEM for two experiments including two to five animals per time point. (ANOVA with Tukey’s HSD post-hoc test; * P < 0.05, ** P < 0.05, *** P < ).
Angela L. Rasmussen et al. Science 2014;346:
Published by AAAS

5. Fig. 4 Distinct host responses associated with disease phenotype.
Distinct host responses associated with disease phenotype. (A and B) Number of differentially expressed genes either up-regulated (positive y axis) or down-regulated (negative y axis) relative to time-matched mock-infected samples in spleen (A) and liver (B).
Angela L. Rasmussen et al. Science 2014;346:
Published by AAAS