1. OTC NSAID Use in Patients With OA and CV Disease

3. Osteoarthritis Scope of Disease

4. NSAID Use in the United States

5. NSAID Risks

6. NSAIDs and Cardiovascular Risk

7. FDA Drug Safety Communication NSAID Use and CV Risk

8. Variables Determining NSAID CV Risk

9. Cyclooxygenase

11. Cardiovascular Syndromes Related to NSAID Use

12. CNT Collaboration

13. Major Vascular Event Risk Comparisons

14. Ibuprofen Blocks Aspirin

15. Cardioprotective Effect of Aspirin Inhibited by Ibuprofen

16. American Association of Orthopedic Surgery (AAOS) Recommendations for Management of OA

17. AAOS Recommendations

18. AAOS Recommendations (cont)

19. ACR Nonpharmacologic Recommendations for OA

20. ACR Pharmacologic Recommendations for OA

21. ACR Recommendations Selecting an NSAID

22. ACR Recommendations

25. Systematic Review of 16 Guidelines

26. Summary: Safe Use of NSAIDs in Patients With CV Disease

27. Abbreviations

28. Abbreviations (cont)