1. Old mice drug-treated for 6 months
Accumulation of p16Ink4a-positive cells
Heart
Eyes
Kidney
Nervous system
Adipose tissue
Lipodystrophy
Reduced activity
Cataracts
Glomerulosclerosis
Kidney dysfunction
Cardiomyocyte hypertrophy
Loss of cardiac stress tolerance
Cancer
Ageing
Reduced healthspan
Old mice drug-treated for 6 months
Specific ablation of p16Ink4a-positive cells
Kidney
Improved renal function
Nervous system
Increased activity
Adipose tissue
Delayed ageing
Increased healthspan
Preserved fat content
Eyes
Reduction in cataracts
Heart
Reduced tumor latency
Recover of cardiac stress tolerance