1. Hereditary Hemochromatosis Manifesting After Treatment of Paroxysmal Nocturnal Hemoglobinuria With Eculizumab 
Elizabeth Elliott, Salman Waheed, Sahr Syed, Sheila Eswaran, Stephanie Gregory, Jamile Shammo 
Clinical Lymphoma, Myeloma and Leukemia 
Volume 18, Issue 1, Pages e9-e12 (January 2018)
DOI: /j.clml
Copyright © 2017 Elsevier Inc. Terms and Conditions

2. Figure 1
Liver Histopathology. On Histologic Examination, the Patient's Liver Biopsy Was Significant for Cirrhosis With Marked Iron Overload (Grade 4 of 4). The Iron Deposition Was Predominantly Present in Biliary Epithelial Cells and Hepatocytes Rather Than in Kupffer Cells. The Portal Area Also Showed Moderate Chronic Inflammation, Likely Secondary and Reactive to Iron Deposition. There Was No Stainable Copper and Alpha-1 Antitrypsin Was Not Identified by Periodic Acid–Schiff–diastase Staining. Overall, the Histologic Pattern and Extent of Deposition Raised Concern for Primary Iron Overload. A, Prominent Iron Accumulation Identified in the Biliary Epithelium and Surrounding Hepatocytes (Hematoxylin and Eosin, ×100); B, A Prussian Blue Stain Highlights Excess Iron Deposition in the Hepatocytes and Bile Ducts (×100); C, A Trichrome Stain Shows Bridging Fibrous Septa and Cirrhotic Nodules in the Biopsy (×40)
Clinical Lymphoma, Myeloma and Leukemia  , e9-e12DOI: ( /j.clml )
Copyright © 2017 Elsevier Inc. Terms and Conditions

3. Figure 2
Patient's Ferritin (ng/ml) and Lactic Acid Dehydrogenase (IU/L) Levels Over Time. Note the Blue Line Represents the Ferritin Level, Whereas the Purple Line Represents the Lactic Acid Dehydrogenase Level
Clinical Lymphoma, Myeloma and Leukemia  , e9-e12DOI: ( /j.clml )
Copyright © 2017 Elsevier Inc. Terms and Conditions