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Volume 119, Issue 2, Pages (August 2000)

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Presentation on theme: "Volume 119, Issue 2, Pages (August 2000)"— Presentation transcript:

1 Volume 119, Issue 2, Pages 377-385 (August 2000)
Central nervous system nitric oxide induces oropharyngeal swallowing and esophageal peristalsis in the cat  Michael J. Beyak, Shuwen Xue, Phillip I. Collman, Diana T. Valdez, Nicholas E. Diamant  Gastroenterology  Volume 119, Issue 2, Pages (August 2000) DOI: /gast Copyright © 2000 American Gastroenterological Association Terms and Conditions

2 Fig. 1 Effects of IV L-NNA on the number of oropharyngeal swallows (MH EMG bursts) in response to water bolus– or SLN-induced peristalsis. The number of EMG bursts (swallows) was significantly reduced in both settings. The effects were not reversed by L-arginine administration. *P < 0.05 compared with control. Gastroenterology  , DOI: ( /gast ) Copyright © 2000 American Gastroenterological Association Terms and Conditions

3 Fig. 2 Effects of IV L-NNA on amplitude of contraction with SLN-induced peristalsis. The amplitude in the smooth muscle section was significantly reduced, whereas the amplitude in the striated muscle section was not significantly affected. The reduced amplitude was not reversed by L-arginine administration. *P < 0.05 compared with control. Gastroenterology  , DOI: ( /gast ) Copyright © 2000 American Gastroenterological Association Terms and Conditions

4 Fig. 3 Effects of IV L-NNA and ICV L-NMMA on the velocity of SLN-induced peristaltic contractions. The peripherally administered NOS inhibitor (L-NNA) significantly increased the velocity of peristaltic contractions in the smooth muscle section; this effect was readily reversed by IV L-arginine. However, the centrally administered NOS inhibitor (L-NMMA) had no effect on the velocity of peristaltic contractions (pooled data from both SLN- and balloon distention–induced peristaltic contractions in smooth muscle section). *P < 0.05 compared with control. Gastroenterology  , DOI: ( /gast ) Copyright © 2000 American Gastroenterological Association Terms and Conditions


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