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Motivation to Eat—AgRP Neurons and Homeostatic Need

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1 Motivation to Eat—AgRP Neurons and Homeostatic Need
Dengbao Yang, Tiemin Liu, Kevin W. Williams  Cell Metabolism  Volume 22, Issue 1, Pages (July 2015) DOI: /j.cmet Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 Optogenetic and Chemogenetic Conditioning of Flavor and Place Cues (A) Animals avoided flavor and place cues associated with optogenetically induced AgRP neuronal activity. Conversely, animals preferred flavor and place cues associated with chemogenetic inhibition of AgRP neurons. (B) AgRP neuronal activity visualized from deep-brain calcium imaging in freely moving mice during different energy states (i.e., nutrient deprived [fasted] and eating). AgRP neuronal activity decreased in the discovery or consumption of food (blue line). Objects of non-nutritive value (false food: red line) failed to sustain decreased AgRP neuronal activity. Cell Metabolism  , 62-63DOI: ( /j.cmet ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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