Presentation is loading. Please wait.

Presentation is loading. Please wait.

Risk stratification of Barrett's oesophagus using a non-endoscopic sampling method coupled with a biomarker panel: a cohort study  Caryn S Ross-Innes,

Similar presentations


Presentation on theme: "Risk stratification of Barrett's oesophagus using a non-endoscopic sampling method coupled with a biomarker panel: a cohort study  Caryn S Ross-Innes,"— Presentation transcript:

1 Risk stratification of Barrett's oesophagus using a non-endoscopic sampling method coupled with a biomarker panel: a cohort study  Caryn S Ross-Innes, PhD, Hamza Chettouh, PhD, Achilleas Achilleos, PhD, Nuria Galeano-Dalmau, MSc, Irene Debiram-Beecham, MSc, Shona MacRae, PhD, Petros Fessas, BA, Elaine Walker, BSc, Sibu Varghese, PhD, Theodore Evan, MBBChir, Pierre S Lao- Sirieix, Maria O'Donovan, FRCPath, Shalini Malhotra, FRCPath, Prof Marco Novelli, FRCPath, Babett Disep, FRCPath, Phillip V Kaye, FRCPath, Prof Laurence B Lovat, FRCPath, Rehan Haidry, FRCPath, Prof Michael Griffin, FRCS, Prof Krish Ragunath, FRCP, Prof Pradeep Bhandari, FRCPath, Adam Haycock, MRCP, Danielle Morris, MRCP, Prof Stephen Attwood, FRCS, Anjan Dhar, FRCP, Prof Colin Rees, FRCP, Prof Matt D Rutter, FRCP, Richard Ostler, MSc, Benoit Aigret, MSc, Peter D Sasieni, PhD, Prof Rebecca C Fitzgerald, MD  The Lancet Gastroenterology & Hepatology  Volume 2, Issue 1, Pages (January 2017) DOI: /S (16) Copyright © 2017 Elsevier Ltd Terms and Conditions

2 Figure 1 Flow chart. NDBO=non-dysplastic Barrett's oesophagus. HGD=high-grade dysplasia. IMC=intramucosal adenocarcinoma. The Lancet Gastroenterology & Hepatology 2017 2, 23-31DOI: ( /S (16) ) Copyright © 2017 Elsevier Ltd Terms and Conditions

3 Figure 2 Examples of significant and non-significant staining for the three protein biomarkers as well as an example of glandular atypia as seen on a Cytosponge sample The Lancet Gastroenterology & Hepatology 2017 2, 23-31DOI: ( /S (16) ) Copyright © 2017 Elsevier Ltd Terms and Conditions

4 Figure 3 Risk classification results for discovery cohort patients
The Lancet Gastroenterology & Hepatology 2017 2, 23-31DOI: ( /S (16) ) Copyright © 2017 Elsevier Ltd Terms and Conditions

5 Figure 4 Intervention follow-up of patients with low-grade dysplasia assigned to high-risk, moderate-risk, and low-risk groups by the Cytosponge risk score The Lancet Gastroenterology & Hepatology 2017 2, 23-31DOI: ( /S (16) ) Copyright © 2017 Elsevier Ltd Terms and Conditions


Download ppt "Risk stratification of Barrett's oesophagus using a non-endoscopic sampling method coupled with a biomarker panel: a cohort study  Caryn S Ross-Innes,"

Similar presentations


Ads by Google