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Epigenetic Noise Fuels Cancer Evolution

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Presentation on theme: "Epigenetic Noise Fuels Cancer Evolution"— Presentation transcript:

1 Epigenetic Noise Fuels Cancer Evolution
Charles Swanton, Stephan Beck  Cancer Cell  Volume 26, Issue 6, Pages (December 2014) DOI: /j.ccell Copyright © 2014 Elsevier Inc. Terms and Conditions

2 Figure 1 Illustration of Intratumor DNA Methylation Heterogeneity
(A) Major types of DNA methylation (DNAm) heterogeneity include variably methylated regions (VMR), long-range epigenetic silencing (LRES), and long-range epigenetic activation (LREA). (B) Schematic bisulfite sequencing reads showing concordant (CR) and discordant (DR) DNAm and formula for calculation of the proportion of discordant reads (PDR). (C) PDR differs in patients with chronic lymphocytic leukemia (CLL) and is associated with adverse clinical outcome. Cancer Cell  , DOI: ( /j.ccell ) Copyright © 2014 Elsevier Inc. Terms and Conditions

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