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Effects of pregnancy and contraception on lamotrigine disposition: New insights through analysis of lamotrigine metabolites  Inger Öhman, Gerhard Luef,

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Presentation on theme: "Effects of pregnancy and contraception on lamotrigine disposition: New insights through analysis of lamotrigine metabolites  Inger Öhman, Gerhard Luef,"— Presentation transcript:

1 Effects of pregnancy and contraception on lamotrigine disposition: New insights through analysis of lamotrigine metabolites  Inger Öhman, Gerhard Luef, Torbjörn Tomson  Seizure - European Journal of Epilepsy  Volume 17, Issue 2, Pages (March 2008) DOI: /j.seizure Copyright © 2007 British Epilepsy Association Terms and Conditions

2 Figure 1 Dose/lamotrigine plasma concentration ratios in 20 non-users of oral contraceptives (controls), 12 users of intrauterine contraception devices containing progestin (CIUD), and 31 users of combined oral contraceptives (COC). Seizure - European Journal of Epilepsy  , DOI: ( /j.seizure ) Copyright © 2007 British Epilepsy Association Terms and Conditions

3 Figure 2 Lamotrigine 2-N-glucuronide/lamotrigine plasma concentration ratios in 20 non users of oral contraceptives (controls), 12 users of intrauterine contraception devices containing progestin (CIUD), and 31 users of combined oral contraceptives (COC). Seizure - European Journal of Epilepsy  , DOI: ( /j.seizure ) Copyright © 2007 British Epilepsy Association Terms and Conditions

4 Figure 3 Lamotrigine 2-N-glucuronide/lamotrigine plasma concentration ratio at different stages of pregnancy and up to three months postpartum in eight women treated with lamotrigine during pregnancy. Seizure - European Journal of Epilepsy  , DOI: ( /j.seizure ) Copyright © 2007 British Epilepsy Association Terms and Conditions

5 Figure 4 Lamotrigine 2-N-glucuronide/lamotrigine urine concentration ratio at different stages of pregnancy and up to three months postpartum in eight women treated with lamotrigine during pregnancy. Seizure - European Journal of Epilepsy  , DOI: ( /j.seizure ) Copyright © 2007 British Epilepsy Association Terms and Conditions


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