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Fig. 3 Urinary LAM concentration predicted pulmonary TB and correlated to mycobacterial burden and weight loss. Urinary LAM concentration predicted pulmonary TB and correlated to mycobacterial burden and weight loss. (A) Box plot of the intensities of LAM in the urine of HIV-negative/TB-positive patients versus controls collected in endemic areas (Wilcoxon signed-rank test). (B) Box plot of the intensities of LAM in the urine of HIV-negative/TB-positive patients stratified on the basis of the auramine staining (low amount of microorganism, scores 0 and 1; high amount of microorganism, scores 2 and 3; Wilcoxon signed-rank test; n = 42). (C) Receiver operating characteristic analysis of the LAM intensity data. AUC, area under the curve. (D) Ordinal regression analysis shows statically significant correlation between the concentration of urinary LAM and the loss of body mass (P = 0.038, n = 37). Luisa Paris et al., Sci Transl Med 2017;9:eaal2807 Published by AAAS
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