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Published byMarie-Dominique Bélanger Modified over 6 years ago
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Parallel Parkin: Cdc20 Takes a New Partner
Fernando Meza-Gutierrez, Frances V. Hundley, David P. Toczyski Molecular Cell Volume 60, Issue 1, Pages 3-4 (October 2015) DOI: /j.molcel Copyright © 2015 Elsevier Inc. Terms and Conditions
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Figure 1 The APC and Parkin Bind and Ubiquitinate Protein Targets through the Substrate Adaptors CDC20 and CDH1 The spindle assembly checkpoint (SAC) and Emi1 regulate the activity of the APCCDC20 and APCCDH1 complexes. The SAC and Emi1 may also regulate the ParkinCDC20/CDH1 complexes. The binding of both CDC20 and CDH1 to Parkin is promoted by phosphorylation of Parkin at Ser378 by Plk1. Molecular Cell , 3-4DOI: ( /j.molcel ) Copyright © 2015 Elsevier Inc. Terms and Conditions
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