1. A 38-Year-Old Woman With an Osteolytic Rib Lesion
Javi Hartenstine, DO, Hope Jackson, MD, Keith Mortman, MD 
CHEST 
Volume 149, Issue 3, Pages e79-e85 (March 2016)
DOI: /j.chest
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2. Figure 1
Initial CT scan of the abdomen and pelvis in the study patient revealing an incidentally found right ninth rib lytic lesion (circle).
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3. Figure 2
Chest radiograph confirming the presence of the lytic lesion (circle).
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4. Figure 3
CT scan of the thorax. (A) Axial and (B) Coronal images revealing an expansile lytic lesion (circles).
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5. Figure 4
Low-power view of fracture and fibrosis with cellular infiltrate and bone destruction. (Original magnification ×4).
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6. Figure 5
Low-power view of cellular medullary lesion and surrounding reactive fibrosis. (Original magnification ×4).
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7. Figure 6
Medium-power view of cellular infiltrate with intervening fibrous septae. (Original magnification ×10).
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8. Figure 7
Histiocyte demonstrating emperipolesis. (Oil emersion, original magnification ×100).
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9. Figure 8
CD-68 immunohistochemical stain results were positive on cellular membranes of histiocytes. (Original magnification ×20).
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10. Figure 9
S-100 immunohistochemical stain results were positive in nuclei and cytoplasm of histiocytes. (Original magnification ×40).
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11. Figure 10
CD1a immunohistochemical stain results were negative on histiocytes. (Original magnification ×20).
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12. Figure 11
CD68 immunohistochemical stain results were positive on cellular membranes of histiocytes. (Original magnification ×20).
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13. Figure 12
Differential diagnoses for solitary lytic bone lesions. ABC = aneurysmal bone cyst; GI = gastrointestinal; GU = genitourinary; MAI/MAC = Mycobacterium avium-intracellulare/Mycobacterium avium complex; UPS = undifferentiated pleomorphic sarcoma (new malignant fibrous histiocytoma).
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