1. Principles of Comparative Effectiveness in PsA and AS

3. Introduction

4. Evolving Complexity of the Treatment Landscape for PsA and AS

5. How Can We Compare the Value of New Agents vs Existing Agents?

6. Desired Situation

7. Also Pretty Good to Have...

8. Current Situation

9. Levels of Evidence and Bias

10. Forms of Bias

11. Forms of Bias

12. Meta-Analysis Is a Form of Observational Research!

13. Meta-Analysis Is a Form of Observational Research! (cont)

14. Indirect Comparison: Standard Approach

15. Indirect Comparison: More Assumptions

16. Correction for PBO

17. Correction for PBO (cont)

18. Correction for PBO (cont)

19. Indirect Comparison: New Approaches

20. Indirect Comparison: New Approaches

21. Indirect Comparison: New Approaches (cont)

22. Indirect Comparisons: Limitations

23. Concluding Remarks

24. Principles of Comparative Effectiveness in PsA and AS

25. The Need for Indirect Comparisons

26. Network Meta-Analysis

27. Network Meta-Analysis

28. Barrier to NMA: Disconnected Networks

29. Matching-Adjusted Indirect Comparison

30. Matching-Adjusted Indirect Comparison (cont)

31. Matching-Adjusted Indirect Comparison (cont)

32. Simulated Treatment Comparisons

33. Simulated Treatment Comparisons (cont)

34. Comparison of Methods: Summary

35. Comparison of Methods: Summary

36. Principles of Comparative Effectiveness in PsA and AS

37. Evolving Complexity of the Treatment Landscape for PsA

38. ADA vs ETA vs INF: Methods

39. ADA vs ETA vs INF: Results and Interpretation

40. ADA vs SEC: Methods

41. ADA vs SEC: Results and Interpretation

42. SEC vs ADA: Methods

43. SEC vs ADA: Results and Interpretation

44. SEC vs INF: Methods

45. SEC vs INF: Results and Interpretation

46. Conclusions

47. Principles of Comparative Effectiveness in PsA and AS

48. Evolving Complexity of the Treatment Landscape for AS

49. ADA vs SEC: Methods

50. ADA vs SEC: Results and Interpretation

51. SEC vs ADA: Methods

52. SEC vs ADA: Results and Interpretation

53. SEC vs ADA: Methods

54. SEC vs ADA: Results and Interpretation

55. SEC vs GOL: Methods

56. SEC vs GOL: Results and Interpretation

57. Conclusions

58. Abbreviations

59. Abbreviations (cont)

60. Abbreviations (cont)