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Cardiometabolic Risk: What Can the PPAR-Alpha Agonists Teach Us?

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Presentation on theme: "Cardiometabolic Risk: What Can the PPAR-Alpha Agonists Teach Us?"— Presentation transcript:

1 Cardiometabolic Risk: What Can the PPAR-Alpha Agonists Teach Us?

2 Panelists

3 Control of Gene Expression by the PPARs

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6 Helsinki Heart Study: Effect of Gemfibrozil on Cardiac Events in Primary Prevention

7 VA-HIT: Effect of Gemfibrozil on Cardiac Events in Secondary Prevention

8 BIP: Effect of Bezafibrate on Cardiac Events in Secondary Prevention

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10 ACCORD Lipid: Hazard Ratios for the Primary Outcome

11 FIELD: Effect of Fenofibrate on the Need for Laser Treatment for Diabetic Retinopathy

12 ACCORD Eye Sub-study: Progression of Diabetic Retinopathy

13 FIELD: Progression and Regression of Albuminuria

14 Impact of PPAR-a on HDL Particles

15 K-877 12-Week Phase 2 Trial: Study Design

16 K-877 12-Week Phase 2 Trial: Results

17 PROVE-IT: Residual CV Risk Remains After Moderate or Intensive Statin Therapy

18 The Concept of Dual PPAR-a/g Agonists

19 ALECARDIO: Aleglitazar in Patients With T2DM and ACS

20 Program Summary

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