1. Bilateral panuveitis in a child: a challenge
Soledad Rubio, MD.
Luisa F. Giraldo, MD
Lidia Cocho, MD.
J.M. Herreras, MD, PhD.

2. 7 07/30/2013 Consult: Bilateral posterior uveitis
January 2013: Follicular conjunctivitis and Skin lesions
Viral exanthema vs. Erythema multiforme (by biopsy). Dependent on oral Acyclovir
January 2013: Anterior uveitis
July 2013: BCVA RE: 20/30; LE: 20/20 IOP: 18 mmHg OU
Slit lamp examination: cells in AC and vitreous (RE>LE)

6. Diagnostic PPV OD Weak positivity to EBV Famciclovir 750 mg daily
Work-up: laboratories, serologies and chest X-ray: negative or normal, except HSV-1 IgG
Bilateral panuveitis + HSV-1 IgG + Systemic rash responsive to Acyclovir
Therapeutic trial with oral Acyclovir 2 g/daily  No clinical improvement after 2 weeks
Diagnostic PPV OD
Weak positivity to EBV
Famciclovir 750 mg daily

7. 11/26/2013
Pre-PPV
Post-PPV

8. 11/06/2014
Iris atrophy OD OS

9. 11/26/2013
11/06/2014
Pre-PPV
VA: OD = 0.8
OS = 1.0

10. Positive for Propionibacterium acnes intravitreal vancomycin x3 +
11/26/2013
11/06/2014
Positive for Propionibacterium acnes
intravitreal vancomycin x3 +
intravenous vancomycin

11. Antivirals and antibiotics failed in inducing remission
02/17/2015
Antivirals and antibiotics failed in inducing remission
Immunosuppression with:
Oral prednisone 1 mg/Kg
Azathioprine 3 mg/Kg
TRAPS
TNFRSF1A gene mutation

12. Last visit 12/01/2016
BCVA OD: 20/200
OS: 20/25-2