1. Roles for microRNA 23b in Regulating Autophagy and Development of Pancreatic Adenocarcinoma 
Massimo Donadelli, Marta Palmieri 
Gastroenterology 
Volume 145, Issue 5, Pages (November 2013)
DOI: /j.gastro
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2. Figure 1
Transcriptional regulation of MIR23B, its targets, and their functions. Transcription of MIR23B is activated by AP-1 and p53, and repressed by c-Myc, nuclear factor (NF)-κB, and chromatin methylation (–CH3). Known targets of MIR23B include mRNAs encoding mitochondrial glutaminase, NADPH oxidase 4, proline oxidase, and peroxiredoxin III (which regulates production of reactive oxygen species), NF-κB, TAK-1–binding proteins 2 and 3 (TAB2 and TAB3; regulators of inflammation and autoimmunity), very low-density lipoprotein receptor (VLDLR), and enterovirus 71 (EV71) and VP1 protein (which inhibit rhinovirus entry and enterovirus replication, respectively). MIR23B also targets mRNAs encoding Atg12 (which activates autophagy), protein kinase A (PKA), VHL, FZD7, MAP3K1, SRC, AKT, urokinase-type plasminogen activator, c-MET, ZEB1, SMAD-3, -4, and -5, and PTEN (a tumor suppressor).
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2013 AGA Institute Terms and Conditions