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CHIPping Away at Base Excision Repair

Published byViktor Niklas Rød Modified over 6 years ago

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Presentation on theme: "CHIPping Away at Base Excision Repair"— Presentation transcript:

1 CHIPping Away at Base Excision Repair
Robert W. Sobol  Molecular Cell  Volume 29, Issue 4, Pages (February 2008) DOI: /j.molcel Copyright © 2008 Elsevier Inc. Terms and Conditions

2 Figure 1 Base Excision Repair Complex Formation and Regulation by Posttranslational Modification Model depicting DNA damage-initiated recruitment of the scaffold protein XRCC1-Lig III and subsequent recruitment of Pol β for the formation of a productive BER complex. Proteins not in a repair complex are subject to CHIP-mediated ubiquitylation and degradation. Question marks underlie the impact of Pol β or XRCC1 PTMs that might alter BER complex formation and CHIP-mediated ubiquitylation as a potential mode for crosstalk to govern BER capacity. Molecular Cell  , DOI: ( /j.molcel ) Copyright © 2008 Elsevier Inc. Terms and Conditions

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