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Germline Susceptibility to Colorectal Cancer Due to Base-Excision Repair Gene Defects  Susan M. Farrington, Albert Tenesa, Rebecca Barnetson, Alice Wiltshire,

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Presentation on theme: "Germline Susceptibility to Colorectal Cancer Due to Base-Excision Repair Gene Defects  Susan M. Farrington, Albert Tenesa, Rebecca Barnetson, Alice Wiltshire,"— Presentation transcript:

1 Germline Susceptibility to Colorectal Cancer Due to Base-Excision Repair Gene Defects 
Susan M. Farrington, Albert Tenesa, Rebecca Barnetson, Alice Wiltshire, James Prendergast, Mary Porteous, Harry Campbell, Malcolm G. Dunlop  The American Journal of Human Genetics  Volume 77, Issue 1, Pages (July 2005) DOI: /431213 Copyright © 2005 The American Society of Human Genetics Terms and Conditions

2 Figure 1 Penetrance curve of the MYH G382D locus. Age-related penetrance was estimated and plotted for all three genotypes, including 95% CIs. The American Journal of Human Genetics  , DOI: ( /431213) Copyright © 2005 The American Society of Human Genetics Terms and Conditions

3 Figure 2 Penetrance curve of the MUTYH gene. All systematically verified and functionally deficient variants were included in the calculations, to estimate the penetrance of the entire gene. This therefore includes variants G382D, Y165C, and nt 9639 a→g. W = wild-type allele; M = mutant allele. The American Journal of Human Genetics  , DOI: ( /431213) Copyright © 2005 The American Society of Human Genetics Terms and Conditions

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