1. Study design.
Study design. Each subject with or without type 2 diabetes participated in euglycemic and hypoglycemic clamp visits separated by 4–8 weeks. Euglycemic clamp preceded hypoglycemic clamps. In the euglycemic clamp visit, blood glucose was maintained at 6 mmol/L for 60 min in the morning and 60 min in the afternoon. In the hypoglycemic clamp visit, blood glucose was maintained at 2.5 mmol/L for 60 min in the morning and 60 min in the afternoon. Blood samples for platelet function, clotting assays, coagulation proteins, and counterregulatory hormones were collected at baseline, end of clamp at 60 min, recovery from morning clamp, and the morning of day 1 and day 7 after the euglycemic and hypoglycemic clamp visits, respectively. EU, euglycemic; HYPO, hypoglycemic.
Elaine Chow et al. Dia Care 2018;41:
©2018 by American Diabetes Association