1. Michael Bukrinsky, M.D., Ph.D.
Professor and Vice-Chair
Laboratory of Molecular Virology
Department of Microbiology, Immunology & Tropical Medicine
(202)

2. HIV-1 Nef induces redistribution
of the main cholesterol transporter, ABCA1
control
Nef

3. Anti-HIV activity of cholesterol efflux-stimulating drugs

4. Studies of HIV nuclear import
Nuclear membrane
vicinity
(Perinuclear area)
MT organizing center
(MTOC)
Aggresome
Proteasomal
degradation p p p p p p _
LEDGF /p75 p
HMGA
Rearrangement of
RTC proteins
Transport
toward MTOC
Termination of
Reverse transcription p p p p p p p + ? ? p ? _ p p ? +
Binding of
importins p
Importin-β p p
Importin-7
Importin-α p p p p p p p _ +
Central
DNA flap
Transport
toward NPC
Importin-α/β MT
Nuclear pore
Complex (NPC)
Nuclear
import
Nuclear envelope
Cytoplasm
Nucleus