1. Chemokines, Chemokine Receptors, and Allograft Rejection
Peter J. Nelson, Alan M. Krensky 
Immunity 
Volume 14, Issue 4, Pages (April 2001)
DOI: /S (01)

2. Figure 1 Multimolecular Complex in Chemokine Action
A multimolecular complex is generally involved in chemokine action. For example, the chemokine RANTES/CCL5 can be presented by a glycosaminoglycan moiety on the endothelial cell surface to a seven-transmembrane-spannning G protein–associated serpentine receptor expressed on the surface of immune cells
Immunity  , DOI: ( /S (01) )

3. Figure 2
Multistep Process in Generation of Inflammatory Infiltrate in Transplant Rejection
A series of chemokine gradients are thought to be required for the recruitment of inflammatory cells from the bloodstream into sites of inflammation
Immunity  , DOI: ( /S (01) )

4. Figure 3
Potential Sites for Therapeutic Intervention in Chemokine Action
(1) Proinflammatory cytokine induction in stromal cells (TNF or IL-1 inhibitors; not shown), (2) early T cell activation (classical immunosuppressives like cyclosporin, tacrilomus, or anti-CD3), (3) gene expression (corticosteroids, novel transactivators), (4) translation and secretion (select cytostatics), (5) binding to endothelium (heparin), (6) serpentine receptors (CCR1 or CXCR3 receptor blockade), and/or (7) G proteins and downstream signal (select kinase inhibitors)
Immunity  , DOI: ( /S (01) )