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Comparison of hyperphosphorylated tau progression

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Presentation on theme: "Comparison of hyperphosphorylated tau progression"— Presentation transcript:

1 Comparison of hyperphosphorylated tau progression

2 Chronic traumatic encephalopathy (CTE)
Comparison of hyperphosphorylated tau progression Chronic traumatic encephalopathy (CTE) From McKee et al. (2013) Stage I Isolated perivascular centers Predilection for depths of sulci within superior, dorsolateral, and inferior frontal cortices Locus coeruleus

3 Chronic traumatic encephalopathy (CTE)
Comparison of hyperphosphorylated tau progression Chronic traumatic encephalopathy (CTE) From McKee et al. (2013) Stage II Multiple centers in frontal, temporal, and parietal neocortices Diencephalon Nucleus basalis of Meynert

4 Chronic traumatic encephalopathy (CTE)
Comparison of hyperphosphorylated tau progression Chronic traumatic encephalopathy (CTE) From McKee et al. (2013) Stage III Widespread neocortical involvement Hippocampus Amygdala Basal ganglia

5 Chronic traumatic encephalopathy (CTE)
Comparison of hyperphosphorylated tau progression Chronic traumatic encephalopathy (CTE) From McKee et al. (2013) Stage IV Medulla Cerebellum Cervical spinal cord

6 Aging/Alzheimer’s disease (AD)
Comparison of hyperphosphorylated tau progression Aging/Alzheimer’s disease (AD) From Braak et al. (2011) Stage a–c Locus coeruleus Upper raphe nuclei Magnocellular nuclei

7 Aging/Alzheimer’s disease (AD)
Comparison of hyperphosphorylated tau progression Aging/Alzheimer’s disease (AD) From Braak et al. (2011) Stage 1a, I–II Transentorhinal cortex Entorhinal cortex

8 Aging/Alzheimer’s disease (AD)
Comparison of hyperphosphorylated tau progression Aging/Alzheimer’s disease (AD) From Braak et al. (2011) Stages III–IV Hippocampus Amygdala Basal temporal cortex Insular cortex Basal frontal cortex

9 Aging/Alzheimer’s disease (AD)
Comparison of hyperphosphorylated tau progression Aging/Alzheimer’s disease (AD) From Braak et al. (2011) Stages V–VI Widespread neocortical involvement Sparing of cerebellum

10 Comparison of hyperphosphorylated tau progression
CTE Aging/AD Stage I Stage a–c Stage II Stage 1a, I–II Stage III Stages III–IV Stage IV Stages V–VI

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