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Health effects of air pollution

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Presentation on theme: "Health effects of air pollution"— Presentation transcript:

1 Health effects of air pollution
Editor: Jonathan A. Bernstein, MD, Contributors: Neil Alexis, PhD, Charles Barnes, PhD, I. Leonard Bernstein, MD, Andre Nel, MD, PhD, David Peden, MD, David Diaz-Sanchez, PhD, Susan M. Tarlo, MB, BS, P. Brock Williams, PhD  Journal of Allergy and Clinical Immunology  Volume 114, Issue 5, Pages (November 2004) DOI: /j.jaci Copyright © 2004 American Academy of Allergy, Asthma and Immunology Terms and Conditions

2 Fig 1 Hierarchic oxidative stress model to PM. At tier 1, antioxidant enzymes restore cellular redox homeostasis. At tier 2, proinflammatory responses are induced. At tier 3, cellular apoptosis-necrosis occurs. GSH, Glutathione; GSSG, oxidized glutathione; NF-κB, nuclear factor κB; MAPK, mitogen-activated kinase; AP-1, Activator protein 1. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2004 American Academy of Allergy, Asthma and Immunology Terms and Conditions


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